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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE2
All Species:
30.91
Human Site:
S159
Identified Species:
45.33
UniProt:
P56282
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56282
NP_002683.2
527
59537
S159
I
G
S
H
P
D
E
S
G
S
K
F
Q
L
K
Chimpanzee
Pan troglodytes
XP_509931
527
59578
S159
I
G
S
H
P
D
E
S
G
S
K
F
Q
L
K
Rhesus Macaque
Macaca mulatta
XP_001095940
525
59213
S162
I
G
S
H
P
D
E
S
G
S
K
F
Q
L
K
Dog
Lupus familis
XP_851216
527
59504
T159
I
G
S
H
P
D
E
T
G
S
K
F
Q
L
K
Cat
Felis silvestris
Mouse
Mus musculus
O54956
527
59368
S159
I
G
S
H
L
E
E
S
G
S
K
F
Q
L
K
Rat
Rattus norvegicus
XP_216727
527
59187
S159
I
G
S
H
P
D
E
S
G
S
K
F
Q
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515002
535
60459
S167
I
G
A
H
P
D
E
S
R
S
K
F
Q
L
K
Chicken
Gallus gallus
Q5ZKQ6
527
59609
N159
V
V
I
H
P
D
D
N
R
S
K
F
Q
L
K
Frog
Xenopus laevis
NP_001083783
527
59670
S159
I
G
S
H
P
D
E
S
R
S
K
F
Q
L
K
Zebra Danio
Brachydanio rerio
NP_775353
527
59243
G159
I
G
S
A
Q
D
E
G
R
N
K
F
Q
L
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_647995
525
58740
A158
Q
D
G
V
G
A
E
A
Q
A
K
K
F
K
L
Honey Bee
Apis mellifera
XP_001120791
454
52119
F111
S
T
I
F
K
D
R
F
E
L
L
W
Y
R
T
Nematode Worm
Caenorhab. elegans
Q19196
534
60979
H164
I
L
G
S
S
T
K
H
L
Q
S
V
V
V
L
Sea Urchin
Strong. purpuratus
XP_796825
501
56117
L150
L
L
G
S
T
A
K
L
G
E
L
I
V
L
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001147081
533
59891
V161
S
K
P
A
F
D
T
V
A
T
E
H
C
S
C
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P24482
689
78322
Q260
E
L
S
N
T
N
R
Q
Q
Q
S
S
S
M
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
92.4
93.5
N.A.
90.1
90.8
N.A.
86.1
82.1
81
73.2
N.A.
42.1
39.2
30.8
57.6
Protein Similarity:
100
99.2
94.3
97.1
N.A.
94.8
95.2
N.A.
90.8
91.4
91
88
N.A.
59.7
58
51.1
75.7
P-Site Identity:
100
100
100
93.3
N.A.
86.6
100
N.A.
86.6
60
93.3
66.6
N.A.
13.3
6.6
6.6
13.3
P-Site Similarity:
100
100
100
100
N.A.
93.3
100
N.A.
93.3
80
93.3
73.3
N.A.
26.6
13.3
20
26.6
Percent
Protein Identity:
N.A.
36.2
N.A.
N.A.
24.3
N.A.
Protein Similarity:
N.A.
56.2
N.A.
N.A.
42.9
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
20
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
13
0
13
0
7
7
7
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
7
% C
% Asp:
0
7
0
0
0
69
7
0
0
0
0
0
0
0
0
% D
% Glu:
7
0
0
0
0
7
63
0
7
7
7
0
0
0
0
% E
% Phe:
0
0
0
7
7
0
0
7
0
0
0
63
7
0
0
% F
% Gly:
0
57
19
0
7
0
0
7
44
0
0
0
0
0
7
% G
% His:
0
0
0
57
0
0
0
7
0
0
0
7
0
0
0
% H
% Ile:
63
0
13
0
0
0
0
0
0
0
0
7
0
0
0
% I
% Lys:
0
7
0
0
7
0
13
0
0
0
69
7
0
7
63
% K
% Leu:
7
19
0
0
7
0
0
7
7
7
13
0
0
69
13
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% M
% Asn:
0
0
0
7
0
7
0
7
0
7
0
0
0
0
0
% N
% Pro:
0
0
7
0
50
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
7
0
0
0
7
0
0
7
13
13
0
0
63
0
0
% Q
% Arg:
0
0
0
0
0
0
13
0
25
0
0
0
0
7
0
% R
% Ser:
13
0
57
13
7
0
0
44
0
57
13
7
7
7
7
% S
% Thr:
0
7
0
0
13
7
7
7
0
7
0
0
0
0
7
% T
% Val:
7
7
0
7
0
0
0
7
0
0
0
7
13
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _